Objective: To evaluate the effects and safety of bupivacaine combined with sufentanil in patient-controlled epidural analgesia (PCEA) after hysterectomy.Methods:52 cases with hysterectomy undergoing PCEA were randomly divided into group I (fentanil 5 μg/ml and 0.1% bupivacaine), n=26, group II (sufentanil 0.5 μg/ml and 0.1% bupivacaine), n=26. The postoperative visual analogue scale and adverse reactions were observed. Results:Compared with the group I, the VSA values are lower during the postoperation (P<0.05 or 0.01). The analgesic effects in group II were considerable, but the incidence rates of adverse reactions in group II were higger than those in group I (P<0.05). Conclusion:The effect of sufentanil combined with bupivacaine in PCEA after hysterectomy is good and safe.