Objective To compare the clinical application advantages and disadvantages of PICC catheter and shallow venipuncture catheter in chronic respiratory failure patients,for provides provides optimization scheme of clinical intravenous infusion.Methods To extract 30 chronic respiratory failure patients who have PICC catheter randomly in respiratory medicine part as experimental group,extract 60 cases who have shallow venipuncture catheter randomly as control group,conparing the daily intravenous infusion time(hours/days) and adverse reaction of two groups patients.Results Two group of patients in daily intravenous infusion time have no obvious difference (p>0.05).The exprimentl group is obviously higher than control group(p<0.05) in the using of parenteral nutrition drug and obviously lower (p<0.05) in the adverse events happen rate .Conclusion Patients with chronic respiratrory faliure in clinical transfusion treatment,using PICC catheter can not only effectively reduce the puncture and guarantee the continuity of the rehydration treatment,but also can improve the safety in the use of special drug and reduce happen rate of adverse events in intravenous infusion.