首页|血清MMP-9水平和颈动脉粥样粥样斑块稳定性与急性脑梗死的相关性及其临床意义

血清MMP-9水平和颈动脉粥样粥样斑块稳定性与急性脑梗死的相关性及其临床意义

The levels of serum MMP-9 and carotid atheromatous plaque stability and acute cerebral infarction and its clinical significance

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
目的：探讨脑梗死患者颈动脉粥样硬化与血清基质金属蛋白酶-g(MMP-9)水平的关系。方法：应用彩色 Doppler 超声诊断仪检测颈动脉内膜中层厚度（IMT），以及有无斑块形成及斑块形态。应用双抗体夹心酶联免吸附法（ELISA）检测100例脑梗死患者的血清MMP-9水平，并进行相关分析。结果：不稳定斑块组空腹血清MMP-9浓度为（549.93±153.12）ng/ml，高于稳定斑块组和无斑块组的（281.45±120.34）ng/ml和（87.36±23.62）ng/ml，差异具有统计学意义（p＜0.01）。结论：血清MMP-9水平的升高，可成为颈动脉粥样硬化斑块易损性的独立预测因素。血清MMP-9水平增高与颈动脉粥样硬化斑块不稳定性密切相关。
Objective:To investigate the relationship between serum MMP-9 levels and carotid atherosclerosis in patients with cerebral infarrtion.Methods:Al carotid arterise of the patieuts were examined with color Doppler ultrasound and intimamedia thickness(IMT)and the shape of plagues were measured.The levels of serum MMP-9 in patients with Cerebral infarction (n=100)were measured respectively.Results:The levels of serum MMP-9 in unstable-plague group was(549.93±153.12)ng/ml,It was significantly higher than(281.45±120.34)ng/ml and (87.36±23.62)ng/ml in the stable-plague group and the non-plague group (p<0.01),resperctively.Conclysions:The elevation of the serum MMP-9 levels may by the independention factors for the wearing of the carotid atherosclerotic plahues.It is closely associated with the occurrence and development of ischemic stroke.

Brain infarctionCarotid arteriesAtherosclerosisMatrix metal oproteinases 9

张晓阳、霍莉

展开 >

山东省莱西市人民医院内二科 266600

脑梗死 颈动脉 动脉粥样硬化 基质金属蛋白酶-9

2013

中国保健营养(中旬刊)
全国卫生产业企业管理协会

中国保健营养(中旬刊)

ISSN：1004-7484
年,卷(期)：2013.(5)
  • 2