Schizophrenia is a severe mental il ness, it affects the global 0.5-1%of the population, is also one of the most serious mental il ness, the rest are various psychiatric diseases have serious cross symptoms, such as bipolar disorder, major depression, at the same time, mental il ness at present mainly by some subjective diagnostic method of self diagnosis in the form of q&a with the development of technology, although added some brain imaging data, but its diagnostic sensitivity and specificity was not good enough, this creates a lot of difficulties on subsequent treatment strategy. Therefore increasingly strong demand for biomarkers, but at the moment about schizophrenia biomarkers are relatively lack, although niacin test detection is applied to some people, but its sensitivity and specificity need further mentioned.