Objective:To analysis and study of hepatic function lesion with tsutsugamushi disease, to guide the diagnosis and cure for tsutsugamushi disease. Methods:The medical history,clinical manifestation and laboratory examination were analyzed by retrospective research method in 46 patients for past 5 years. Results:45 patients were activity in field or sit on grassland.45 patients were fever. 41 patients were distinctive eschar or ulcer. Liver function was improved in 1 week and normal in 2 or 3 weeks by chloramphenicol or doxycycline with liver aid. Conclusions:Activity in field or sit on grassland was important important. The distinctive eschar or ulcer was important feature for diagnosis of tsutsugamushi disease. The hepatic function lesion with was mild or midrange. Chloramphenicol and doxycycline was effective for tsutsugamushi disease.