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恙虫病致肝功能损害的临床研究

The clinical research of hepatic function lesion with tsutsugamushi disease

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目的:探讨恙虫病所致肝功能损害的临床特点,为临床诊治恙虫病性肝功能损害提供参考依据。方法:回顾性分析46名恙虫病并发肝功能损害患者病史特点、临床表现、实验室检查等,分析总结恙虫病致肝功能损害患者的临床诊治要点和注意事项。结果:45例患者均有野外活动或坐卧草地史,均有发热,41例出现特征性的焦痂或溃疡。患者血清ALT在82~460U/L之间,AST在65~360U/L之间。使用氯霉素或多西环素等抗恙虫病立克次体并辅以护肝药物治疗,1周后肝功能均有不同程度好转,2~3周后所有患者肝功能基本恢复正常。结论:野外活动或坐卧草地史为恙虫病重要病史特点,出现特征性的焦痂或溃疡为确诊恙虫病重要体征,恙虫病所致肝功能损害一般为轻中度,氯霉素和多西环素可有效控制恙虫病立克次体感染,辅以护肝治疗肝功能一般可顺利恢复正常。
Objective:To analysis and study of hepatic function lesion with tsutsugamushi disease, to guide the diagnosis and cure for tsutsugamushi disease. Methods:The medical history,clinical manifestation and laboratory examination were analyzed by retrospective research method in 46 patients for past 5 years. Results:45 patients were activity in field or sit on grassland.45 patients were fever. 41 patients were distinctive eschar or ulcer. Liver function was improved in 1 week and normal in 2 or 3 weeks by chloramphenicol or doxycycline with liver aid. Conclusions:Activity in field or sit on grassland was important important. The distinctive eschar or ulcer was important feature for diagnosis of tsutsugamushi disease. The hepatic function lesion with was mild or midrange. Chloramphenicol and doxycycline was effective for tsutsugamushi disease.

Hepatic function lesiontsutsugamushi disease

梁少群(通讯作者)、吴兴柳、赵明聪、丁佩佩、吴贺明

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中山大学附属江门市中心医院感染科 529070

恙虫病 肝功能损害

2013

中国保健营养(中旬刊)
全国卫生产业企业管理协会

中国保健营养(中旬刊)

ISSN:1004-7484
年,卷(期):2013.(6)
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