首页|探讨血小板活化参数在冠心病诊断和预后的意义

探讨血小板活化参数在冠心病诊断和预后的意义

To explore platelet activation parameters as diagnostic and prognosis markers in thecourse of coronary disease

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  • NETL
  • NSTL
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目的：评估血小板活化参数（L-PLT，PCT，MPV，MPM，MPC）在冠心病的进展过程中作为诊断和预后标志物的可行性。方法：采用酶免疫分析法测定Tn1(心肌肌钙蛋白质)，CK-MB（肌酸激酶），纤维蛋白原和D二聚体水平，并对它们的诊断敏感性进行比较。结果：血小板活化参数（L-PLT，PCT， MPV，MPM，MPC）随着心血管疾病的进展而增加，作为冠心病的诊断和预后标志物，其敏感性要高于Tn1(心肌肌钙蛋白质)，CK-MB（肌酸激酶），纤维蛋白原和D二聚体。结论：血小板活化参数（L-PLT，PCT，MPV，MPM，MPC）在冠心病进展过程中不稳定动脉粥样化的风险评估时可以充当诊断和预后标志物。
Objectives: To evaluate the feasibility of platelet activation parameters served as diagnostic and prognostic marker in the course of coronary disease. Methods: platelet activation parameters, Tn1(cardiac troponin I), CK-MB (creatine kinase-heart type), fibrinogen and DD (D-dimers) were measured with an enzyme immunoassay (Bio-Check) and diagnostic sensitivity was compared among them. Result: platelet activation parameters, concentration increase systematical y with the advancement of coronary artery disease. As diagnostic and prognostic marker for coronary artery disease, the sensitivity is higher than that of TnI, CK-MB and DD. Conclutions: Platelet activation parameters may serve as at ractive diagnostic and prognostic markers in the assessment of the risk for unstable atheroma in the course of coronary artery disease.

coronary artery diseaseplatelet activation parametersDiagnosticprognostic

熊纭辉、聂劼、王喜文

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广东省深圳市宝安区福永人民医院 广东 深圳 518103

广东省深圳市宝安区妇幼保健院 广东 深圳 518103

冠心病 血小板活化参数 诊断 预后

2013

中国保健营养(中旬刊)
全国卫生产业企业管理协会

中国保健营养(中旬刊)

ISSN：1004-7484
年,卷(期)：2013.(6)
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