OBJECTIVE:To investigate the psychological state of anxiety, depression and nursing care countermeasures of patients with chronic hepatitis B.METHODS:Adopt the Self-rating Anxiety Scale (SAS) and self-rating depression scale (SDS) compiled by Wil am and WK Zung, investigate and analysis the anxiety, depression psychological reaction of 158 patients of chronic hepatitis B and take the corresponding nursing countermeasures. RESULTS:58 patients with chronic hepatitis B has a high incidence rate on anxiety, depression. CONCLUSION:According to different psychological status,take active nursing intervention measures on patients with chronic hepatitis B, can quickly improve symptoms, improve the curative effect.