Objective: To investigate clinical treatment effect for uterine fibroids by vaginal myomectomy and abdominal myomectomy. Methods: Clinical data of 94 patients with uterine fibroids in our hospital from February 2012 to February 2013 were reviewed . The treatment group(47) treated by vaginal myomectomy and the control group (47) treated by abdominal myomectomy. Results: After treatment,The total effective rate of the treatment group was significantly higher than that of the control group( P<0.05 );The operation time ,hospitalization time, blood loss and anal exsufflation time were significantly lowetr than that of the control group(P<0.01).Conclusion:Vaginal myomectomy treatment for uterine fibroids have significant clinical efficacy and lower cost of treatment.