Objective: To investigate clinical effect for uterine fibroids by vaginal hysterectomy and abdominal hysterectomy. Methods: 100 case of uterine fibroids in our hospital from August 2009 to February 2013 were divided into vaginal hysterectomy group (50) and abdominal hysterectomy group (50). The operative time , blood loss, postoperative morbidity , postoperative hospital stay and recovery time of intestinal function were analyzed. Results: After treatment,the difference of operative time and postoperative morbidity between two groups was not significant ( P>0.05 ) ;The blood loss ,hospitalization time and anal exsufflation time of vaginal hysterectomy group were significantly lowetr than that of abdominal hysterectomy group(P<0.01).Conclusion:Vaginal hysterectomy treatment for uterine fibroids have significant clinical efficacy .