Objective: To explore the role of high dose of atorvastatin on myocardial preservation of acute myocardial infarction after thrombolysis treatment. Methods:Analyzed the CK-MB, cTnⅠ, sVCAM-1, sICAM-1 and BNP changes of the high dose of atorvastatin (Observation group, n = 40) or low dose of atorvastatin (Control group, n = 40) for treatment of 80 newborn patients with acute myocardial infarction after thrombolysis treatmentin our hospital from February 2010 to May 2012. Results: 24 hours after thrombolysis treatment the CK-MB, cTnⅠ, sVCAM-1, and sICAM-1 in the observation group were significantly lower than those in the control group. 1 month after thrombolysis treatment the cTnⅠ, sVCAM-1, sICAM-1, and BNP in the observation group were significantly lower than those in the control group. Moreover, the arrhythmia rate 2 hours after thrombolysis and cardiac events rate between 6 months after treatment in the observation group were significantly lower than those in the control group. Conclusions: High dose of atorvastatin on myocardial preservation acute myocardial infarction after thrombolysis treatment has more significant role. It is worthy to be popularized.
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