objective: to study the configuration of parenteral nutrient solution methods to affect the quality of nutrient solution and the quality of parenteral nutrient solution configuration of control measures. Methods: according to clinical practice experience, the paper expounds the configuration of parenteral nutrient solution method to influence the quality of nutrient solution, from the configuration environment, configuration, personnel, prescription audit, specification configuration method, infusion five aspects to strengthen quality control and storage requirements. Results: after control, effectively improve the quality of the parenteral nutrient solution, to ensure the safe use of parenteral nutrient solution. Conclusion: the preparation of parenteral nutrient solution to operation process in strict accordance with the specification, configuration environment must meet the requirements, must strengthen the control of the preparation and configuration actions, do a good job cleaning, disinfection, strict aseptic operation, strengthen the understanding of parenteral nutrient solution, the configuration process and configuration skil s, to take bet er measures to enhance the quality of the nutrient solution.