Over the years, Yao mine has a high silicosis incidence rate, which has a great harm to the physical and mental of the workers and brings the families and company heavy economic burden, thus constrains and influences the health of Yao mine. In this paper, the damage degree of dust of the mine workplace was analyzed and the silicosis patients were investigated. On the basis of the above work, the factors of silicosis were analyzed, related strategies and targeted control measures were brought out, al these can contain the silicosis effectively.