Objective: To explore the nursing measures of patients with tracheal escrow analysis of brain injury after operation, improve the ability of emergency nursing cooperation during operation, reduce the operation time, reduce the mortality rate of patients. Methods: the summary of 137 cases of craniocerebral injury patients in the emergency operation During the nursing process, key points and clinical experience. Results: 137 cases of craniocerebral injury patients after operation 120 cases were rescued successful y, the success rate was 87.59%, death 17 cases, including 7 cases in the operation process of death, more than 10 cases mainly because of severe contusion and laceration of brain hernia, the brainstem damage resulting in central failure cause of death. Conclusion: operation room nurses should master the rescue method and advanced detection technology, also have a clinical observation, analysis and emergency response ability, to cooperate with the doctors for relevant measures operation in the operation, to improve the success rate of rescue operation is important.