The clinical efficacy and safety of citalopram and mecobalamin in the treatment of the peripheral neuropathy which is caused after the oxaliplatin chemotherapy in malignant glioma
Objectives:Obeserve the clinical efficacy and safety of citalopram and mecobalamin in the treatment of the peripheral neuropathy which is caused after the oxaliplatin chemotherapy in malignant glioma. Methods:Choose 68 cases of the peripheral neuropathy disease patients who are caused after the oxaliplatin chemotherapy in malignant glioma at our hospital form 2009 to 2012, random grouping by computer, it can be divided into the experimental group and control group, each group was 34 cases,both of two groups of patients were given the same basic symptomatic treatment,meanwhile the experimental group were treated by citalopram and mecobalamin, and control group were treated with vitamin B12 therapy, observed the overal effective treatment and nerve conduction velocity,the occurrence of adverse events of two groups of patients. Results:the overal treatment efficiency of the experimental group of patients was significantly higher than the control group (P < 0.05), the nerve conduction velocity of the experimental group of patients was also significantly faster than the control group (P <0.05), both of two groups had no significant adverse reactions. Conclusions:The clinical efficacy of citalopram and mecobalamin in the treatment of the peripheral neuropathy which is caused after the oxaliplatin chemotherapy in malignant glioma is distinct,the safety is high.
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