Object:To observe the efficacy and safety of the combined application of Tacrolimus and moderate dose glucocorticoid in the treatment of refractory IgA nephropathy.Method:Forty-three patients with refractory IgA nephropathy were randomized to the single Glucocorticoids group(Prednisone 30 mg?d-1) and drug combination group(combined medication of Prednisone 30 mg?d-1 and Tacrolimus 1 mg?d-1). The blood trough concentration of tacrolimus was maintained at 3-7ng?dl-1. Before and after treatment of 4 weeks, 12 weeks and 24 weeks, the detection result including 24-hour urinary protein excretion, Urinary red blood cellcount, Urine specific gravity, CCr, BUN, Cr, TP, ALB, AST, ALT, GLU and the Adverse Reaction, were recorded and analyzed.Result:To the contrast, in BUN、Cr、TP、AST、ALT and GLU, there were no difference between the groups (P >0.05). Compared with the single Glucocorticoids group, 24-hour urinary protein excretion, Urinary red blood cellcount, Onset time, Complete remission rate and ALB were significantly bet er in drug combination group (P<0.01).Conclusion:Compared with monotherapy, combination of Tacrolimus and moderate dose glucocorticoid can provides bet er efficacy, which also provides a new direction for the treatment of Refractory IgA nephropathy.
Refractory IgA nephropathyGlucocorticoidsTacrolimus
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