Objective:To observe the clinical effect of Wuling Powder and Wupi Drink in the treatment of cirrhosis ascites.Method:The 89 patients were divided into two groups randomly, 31 of them were put into the control group, and the other 58 were put into the treatment group. The control group was given oral hydrochlorothiazide, 25mg tid, and spironolactone, 20mg tid. The treatment group was treated with a combination of Wuling powder and Wupi drink. Col ect the symptomatic grading and the score of the scales after observation.Results:The total effective rate of the treatment group were 98.3%, which was higher than the total effective rate in controls which is 83.7%.(P<0.05).Conclusion:Experiments proves that Wuling powder and Wupi drink in combination works in the treatment of cirrhosis ascites and is worth to generalize the use of it.