objective:to investigate and analyze the brain surgery nursing safety problems and the corresponding preventive measures. Method:Research materials for our brain surgery from 2011 to 2013, since its nursing safety hazard analysis and preventive measures of medical disputes, carry on the statistics and analysis, to seek effective measures to prevent brain safe hidden trouble. Results:In nursing safety hazard analysis and protection measures to significantly reduce the medical dispute since the event. Conclusion:The effective preventive measures can be resolved in a timely manner, to avoid and prevent nursing dispute, provides patients with safe, rest assured, satisfaction of nursing service. For the protection of nursing staff and improve the effect of the treatment of patients with al have the important meaning.