Effects of different statins on Change of hs-CRP after stent implantation in patients with Acute myocardial infarction
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目的：探讨瑞舒伐他汀和阿托伐他汀对急性 ST段抬高型心肌梗塞患者行急诊冠脉介入治疗（PCI)术后血清高敏 C 反应蛋白（hsCRP)水平和心血管事件的影响。方法：选择我院急性ST段抬高型心肌梗塞并行急诊PCI的患者患者152例为研究对象，将其随机分为20mg瑞舒伐他汀组（76例）和40mg阿托伐他组（76例）。在常规给予冠心病二级预防治疗的基础上，两组分别给予20mg瑞舒伐他汀组、40mg阿托伐他组维持治疗一个月，并分别于术前、术后24小时、术后1周及术后1月采集患者静脉血，测定血清hsCRP水平，观察1个月时心血管事件发生率。结果：入院时（PCI术前）2组间患者的hsCRP水平比较差异无统计学意义（P>0.05)，术后24小时与术前比较，血清 hsCRP水平均有明显升高（p<0.05)，但两组间比较差异无统计学意义（P>0.05)。PCI术后1周和术后1月时，与阿托伐他汀组比较，20mg瑞舒伐他汀组hsCRP水平降低，差异有统计学意义(P＜0.05)。瑞舒伐他汀组心血管事件发生率稍低，但两者比较，差异无统计学意义（P>0.05)。结论：瑞舒伐他汀及阿托伐他汀两组均可使急性心肌梗塞患者行急诊冠脉介入术后的炎症因子水平明显降低，且20mg瑞舒伐他汀比40mg阿托伐他汀抗炎效果更明显。两者都能明显减少心血管事件的发生。
Objective:To evaluate the effect of rosuvastatain and atorvastatin on serum levels of high-sensitivity C-reactive protein(hsCRP) in patients with acute ST segment elevation myocardial infarction after acute percutaneous coronary intervention(PCI). Methods:This study included 152 patients with PCI in the hospital, who were randomly divided into two groups:20mg rosuvastatain treatment group ( n=76), and 40mg atorvastatin treatment group ( n =76). Based on routine treatment, 20mg rosuvastatin or 40mg atorvastatin were added starting before PCI For a month. The serum hsCRP levels were measured before PCI and after PCI 24 hours, 1 week as wel as 1month. Results:The differences of hsCRP between the two groups were not significantly different before PCI, at 24 hours after PCI ( P >0.05),the data were Significantly increased p<0. 05).In postoperatively for 1 week and 1 month,hsCRP decreased in 20mg rosuvastatain treatment group compared with 40mg atorvastatin treatment group , the difference were significant( P<0. 05). The incidence of cardiovascular events in the rosuvastatin group was lower than that in the atorvastatin group, but it showed no significant difference between two groups( P>0.05) . Conclusion:Treatments with rosuvastatain and atorvastatin also could reduce hsCRP levels after stent implantation in patients with Acute myocardial infarction .The hsCRP level decreased more significantly in 20mg rosuvastatain treatment group compared with 40mg atorvastatin treatment group.Both of them can decrease the incidence of acute myocardial infarction significantyly.
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