Objective:To investigate the origin of high sensitive C-reactive protein (hsCRP) in spontaneously hypertensive rats (SHR). Methods:SHRs were used to detect the dynamic changes of their serum hsCRP concentrations. Meanwhile, the CRP expression levels in aortic smooth muscle and liver were also examined both in protein and mRNA during the formation of hypertension. Results:After five weeks old, the systolic pressure of SHR elevated with the increase of week-old. The levels of serum hsCRP and CRP expression in aorta were also increasingly raised, while CRP expressions in liver were low consistently. The analysis of correlation showed that there had positive correlation between the levels of systolic pressure and the concentrations of serum hsCRP, as while as between the levels of CRP expression in aortic smooth muscle and the concentrations of serum hsCRP. However, correlations were not observed between the levels of CPR expression in liver and the serum hsCRP. Conclusion: The elevated hsCRP levels in SHR mainly originate from aortic smooth muscle not from liver.
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