首页|脑梗塞并代谢综合征血清瘦素、TNF水平与颈动脉斑块性质的关系

脑梗塞并代谢综合征血清瘦素、TNF水平与颈动脉斑块性质的关系

The relationship of serum leptin and TNF with carotid plaque’s character in Acute erebral infarction complicated by metabolic syndrome

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目的：探讨急性脑梗塞（ACI）并代谢综合征（MS）患者颈动脉斑块性质以及与血清瘦素、TNF的关系。方法：将126例通过彩色多普勒筛查出有颈动脉粥样硬化斑块的ACI患者分为MS组及非MS组，比较两组血清瘦素、TNF水平，借助1.5T核磁共振血管成像(CE-MRA)对颈动脉进展期斑块进行统计，并做比较。运用多元逐步logistic回归分析ACI并MS患者血清瘦素、TNF水平及与颈动脉进展性斑块的关系。结果：ACI并MS组血清瘦素、TNF水平明显高于非MS组（P<0.05）,MS组颈动脉进展性斑块发生率高于非MS组（P<0.05），ACI并MS患者血清瘦素、TNF水平与颈动脉进展性斑块具有相关性（OR=0．073, P<0.05）。结论：MS是脑血管病重要危险因素，血清瘦素、TNF可能是颈动脉斑块进展的原因之一。
Objective:To explore the relationship of serum leptin and TNF with carotid plaque’s character in Acute erebral infarction (ACI)complicated by metabolic syndrome(MS).Method:126 ACI patients with carotis plaque were selected by transcranial Doppler were divided into MS group and non-MS group.The levels of serum leptin and TNF were compared in two groups. Carotis developed plaque in two groups were statistic and compared. The relationship of serum leptin and TNF with carotid plaque’s character in ACI complicated by MS were examined by Multiple logistic regression analysis·Result:The levels of serum leptin and TNF of ACI with MS were higher than those of ACI with non-MS.The incident of Carotis developed plaque in ACI with MS were higher than in ACI with non-MS.There was positive correlation beteen the levels of serum leptin and TNF with the incident of carotis developed plaque in ACI with MS(OR=0.073, P<0.05). Conclusion:MS is important risk factor of erebral infarction. The levels of serum leptin and TNF may be one of factors of Carotis developed plaque.

Acute erebral infarctionmetabolic syndromeleptinTNFcarotid plaque

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四川省绵阳市中心医院神经内科 四川 绵阳 621000

急性脑梗塞 代谢综合征 瘦素 肿瘤坏死因子 颈动脉斑块

2013

中国保健营养(中旬刊)
全国卫生产业企业管理协会

中国保健营养(中旬刊)

ISSN：1004-7484
年,卷(期)：2013.(11)