objective: to analysis and observation of lamotrigine combination therapy in the treatment of refractory epilepsy children application effect.Methods:Investigate 35 patients were diagnosed intractable epilepsy from August 2011 to August 2013 in Panzhihua Central Hospital pediatric clinic,who treated with lamotrigine combined with sodium valproate ,and compared with before the combination therapy with a seizure frequency, at the same time observation of combination therapy of adverse reactions. Results:compared with before treatment, after treatment in children with epileptic seizure frequency is less, there is statistical significance difference (P<0.05);Effective of the 20 cases , markedly effective of the 9 cases;5 cases of no avail, 1 case of deterioration, the treatment effective rate was 82.8%. After combination, some patients have different degrees of dizziness, rash, nausea, loss of appetite and other adverse reactions, the incidence was 11.4%. Conclusion:to give children with intractable epilepsy lamotrigine combined with sodium valproate treatment, can improve the disease clinical curative effect, less adverse reaction, children can tolerance, good security.
lamotrigine. Combination therapyRefractory epilepsy in children
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