Objective:To study the relationships of the patients with chronic severe hepatitis B serological typing (HBV-M), viral load (HBV-DNA) and the changes of coagulation function. Methods:Study of the Institute of clinical diagnosis of chronic severe hepatitis B inpatients 141 cases, control group for the same period in 46 cases of health physical examination personnel .The patients and medical staff of serologic markers (HBV-M) were detected by enzyme-linked immunosorbent assay (ELISA), viral load (HBV-DNA) was detected by fluorescence quantitative polymerase chain reaction (FQ-PCR) and the coagulation function[prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time (TT),and plasma fibrinogen(FIB)]was also detected. According to HBV-M, al the objects were divided into five groups respectively:group A (HBsAg+HBeAg+HBcAb+), group B (HBsAg+HBeAb+HBcAb+), group C (HBsAg+HBcAb+), group D (HBsAg+HBeAb+), E group (HBsAg+), F group (HBeAb+). And the patients were classified as seven groups according to HBV-DNA load respectively:group1(HBV-DNA≤103), group2(103 <HBV-DNA≤104), group3(104<HBV-DNA≤105), group4(105<HBV-DNA≤106), group5(106<HBV-DNA≤107), group6(108<HBV-DNA),Then each group was compared to coagulation function, and the results were statistical y analyzed. Results:A significant difference was found between each group of blood coagulation in 141 cases of patients with chronic severe hepatitis B and control group (p<0.05), and that has relation with the HBV-M and HBV-DNA load. PT, APTT and TT had positive correlation with HBV-M and HBV-DNA, but FIB had negative correlation. Conclusion:There are relationships between coagulation function changes and HBV-M and HBV-DNA load in patients with severe chronic hepatitis. The three indicators changed can provide the important value for this type of patients of treatment and curative effect judgment.
Chronic severe hepatitis B virusSerological typingViral loadCoagulation function
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