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培菲康联合三联疗法根除幽门螺杆菌疗效观察

Clinical observation of Bifidobacterium,lactobacillus and Enterococcus capsules combined with triple therapy in eradicating helicobacter pylori infection

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目的：探讨一种安全、有效的幽门螺杆菌（Hp）感染相关消化性溃疡的有效治疗方案，评价标准三联疗法加用微生态制剂Hp根除方案的疗效。方法：2009年1月至2009年12月符合Hp感染相关消化性溃疡诊断标准的66例患者，随机分为三联治疗对照组和三联治疗组+微生态制剂，雷贝拉唑10mg、克拉霉素0.5、甲硝唑0.4；治疗组36例，对照组32例，Bid×10d，之后治疗组予以双岐杆菌活菌制剂0.42bid*14d，对照组安慰剂治疗14d。系统治疗完成后4周复查胃镜及13C-尿素呼气试验检测H.pylori。结果：治疗组痊愈20/36例(55.8％)，有效11/36例(30.6％)，无效5/36例(13.9％)，总有效率为86.1％；对照组痊愈15/32例(46.9％)，有效7/32例(21.9％)，无效10/32例(31.2％)，总有效率为68.8％,两组H.pylori根除率及总有效率比较有统计学差异（P<0.05）。且观察组不良反应发生率明显低于对照组。结论：微生态制剂联合三联疗法根除方案治疗H.pylori感染相关溃疡总有效率优于单纯三联疗法，且有不良反应低的优点。
Objective:To investigate Live combined Bifidobacterium,lactobacil us and Enterococcus capsules combinded with triple therapy of Helicobacter pylori infection associated peptic ulcer clinical efficacy. Methods:From Jan 2012 to Dec 2012, 68 cases of patients with peptic ulcer data were randomly divided into observation group and control group, 32 cases in the control group were treated with triple therapy;36 cases in the observation group .After 10days triple therapy. observation group took Live combined Bifidobacterium,lactobacil us and Enterococcus capsules ,2#, tid×14d. Four weeks after the end of treatment, ulcer patients endoscopy to observe H.pylori infection and ulcer healing degree;the 13C-urea breath test, H.pylori eradication rate was observed. Also observed adverse reactions in patients. Results:The patients H.pylori clearance rate ,the total effective rate is 86.2%and there is a low incidence of adverse reactions in the observation group, There is a significantly difference between tow groups (P<0.05). Conclusion:The combination of Live combined Bifidobacterium,lactobacil us and Enterococcus capsules with triple therapy treated Helicobacter pylori infection, the clinical results were satisfactory, worthy of clinical application.

Live combined Bifidobacterium,lactobacillus and Enterococcus capsulesTriple therapyHelicobacter pyloriPeptic ulcer

高泽立、张成、金丽雯、宣思红、盛飞英

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上海市浦东新区周浦医院消化科 上海 201318

幽门螺杆菌 消化性溃疡 微生态制剂

2013

中国保健营养(中旬刊)
全国卫生产业企业管理协会

中国保健营养(中旬刊)

ISSN：1004-7484
年,卷(期)：2013.(11)
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