Objective:to observe the effect of ovariectomy and dexamethasone intramuscular on vascular calcium content and bone density of rat. Methods:the female Wistar rats were separately deal with the ovariectomy and muscle injection of dexamethasone, to observe the effects on vascular calcium content and bone mineral density. Female Wistar rats were divided into 4 groups, namely the control group, sham-operation group, ovariectomy group and the dexamethasone injection group, 10 weeks later, aortic calcium, alkaline phosphatase(ALP) activity and osteocalcin (OC) content were determinated, to reflect the degree of vascular calcification; Rat bone density is measured by bone mineral density instrument to reflect the degree of osteoporosis. Results:the ovariectomy group and dexamethasone injection group vascular calcium were elevated, were significantly higher than the control group and sham-operation group (P<0.01);the lumbar vertebra bone mineral density were lower than that of control group in the two groups (P<0.01, P<0.05), the femoral bone mineral density in ovariectomy group is lower than that of the control group (P<0.05). Conclusions:the ovariectomy and muscle injection of dexamethasone to rat may lead to bone mineral density reduce, at the same time can increase the blood calcium content, its mechanism remains to be further discussed.
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