Objective:To investigate The clinical effect and impact on inflammatory factors by Anti-inflammatory agent treatment in upper respiratory tract infection patients.Methods:120 patients with upper respiratory tract infection were randomly divided into two groups, anti-inflammatory agent group and the conventional treatment group.The clinical effect was observed three days later.On the 1st and 5th day after the treatment began, IL-1 and PCT were respectively detected by ELISA and immunochromatography assay.Results:Clinical effective rate is relatively higher, referral rate is relatively lower, IL-1 significantly decreased, in the Anti-inflammatory agents group than the conventional treatment group (P<0.05).PCT was not significant change before and after treatment, and no Difference between the two groups (P> 0.05) Conclusion:The anti-inflammatory agents can inhibit IL-1 levels,and the clinical effect is obvious in the upper respiratory infection patients.