objective:To observe the efficacy of 308 excimer laser irradiation combined with Fufang kali ziran ding in the treatment of Vitiligo of face and neck and trunk in stable. Methods:68 patients were randonly divided inti treatment group and control group. treatment group:In addition to external use fufang kali ziran ding,combined with 308 excimer laser irradiation.control group:Only external use fufang kali ziran ding ,without 308 excimer laser irradiation.Results:treatment group was higher, difference was statistical y significant.Conclusion:The effect 308 excimer laser irradiation combined with Fufang kali ziran ding therapy in the treatment of vitiligo of face and neck and trunk in stable is significantly.