objective:to observe the clinical effect of the patients who prophylactic use of antibiotics in cesarean section perioperation .Method:we chose 364 patients who accepted cesarean section to be the object of study from 2013 April to 2014 January in our hospital,And were randomly divided into control group of 180 cases and 184 cases in the study group.The control group used antibiotics after operation,and the study group used antibiotics in preoperative, intraoperative and postoperative.The routine use 2-3 days and may extend the application of time according to the condition.Clinical effect after operation were compared between the two groups.Result:1. We found statistics significance between the two groups in postoperative temperature, change of hemogram, the cooling time, antibiotic dosage after different treatment(P<0.05);2.And we also found that it had statisticaly significant differences in the days of hospitalization、postoperative medication、expenses and patient satisfaction(P<0.05).Conclusion:It has good clinical effect of prophylactic application of antibiotics and is worth the clinical promotion.