首页|胰岛素类似物短期强化血糖控制对初诊2型糖尿病患者的疗效观察

胰岛素类似物短期强化血糖控制对初诊2型糖尿病患者的疗效观察

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目的：观察胰岛素类似物短期强化治疗初诊2型糖尿病(T2DM)的疗效。方法：将88例初诊T2DM患者随机分为胰岛素类似物多次皮下注射组（观察组）和胰岛素泵组（对照组），每组各44例，连续治疗ZW，分别于治疗前后测空腹血糖（FPG）、空腹胰岛素（FINS）、空腹C肽（FC-P）及进食100g标准淀粉馒头后2h血糖（2hPG）、2h胰岛素（2hINS），2hC肽（2hC-P），并分别计算HOMA-IR、HOMA-，记录血糖达标时间、达标日胰岛素类似物用量，低血糖发生频率。结果：治疗后两组FINS、FC-P、2hINS、2Hc-P、HOMA-较治疗前明显升高（P＜0.01）、FPG、2hPG、HOMA-IR明显下降（P＜0.01）；两组间比较，治疗前和治疗后FINS、FC-P、2Hc-P、HOMA-、FPG、2hPG、HOMA-IR无统计学差异（P＞0.05），低血糖发生过频率无统计学差异（P＞0.05）达标时间胰岛素泵组（2.46+0.78）d明显短于胰岛素类似物组（5.42+1.76） d（p＜0.05），达标日胰岛素类似物用量胰岛素泵组（31.25+9.12）U/d，略少于胰岛素类似物皮下注射组（36.43±8.24u/d）但无统计学差异（p＞0.05）。随访6个月，两组患者在饮食运动治疗下，多数血糖均控制良好，需药物治疗的比例无明显差别。结论：胰岛素类似物短期强化治疗初诊T2DM能明显改善胰岛β细胞功能，降低胰岛素抵抗，使多数血糖较高的初诊T2DM患者在长期不服药的情况下，血糖得到良好控制，可取的胰岛素泵强化治疗相似的效果。
Insulin analogue short-term improved glycemic control with insulin pump was to the curative effect of patients with type 2 diabetes control study
Oobjective:To observe the insulin analogue short-term intensie treatment the curative effect of new type 2 diabetes melitus (T2DM).Methods:88 new T2DM patients were randomly divided into multiple subcutaneous injections of insulin analogues group (observation group) and insulin pump group (control group), each group of 44 cases, continuous treatment of ZW, respectively before and after treatment to measure fasting blood glucose (FPG), fasting insulin (FINS), fasting C peptide (FC - P) and 2 h blood sugar after eating 100 g starch steamed bread (2 HPG), insulin (2 hins), 2 h 2 hc peptide (2 hc - P), and calculate the HOMA IR, HOMA, record blood glucose control is at target time, standard, dosage of insulin analogs, the frequency of hypoglycaemia.Results:After treatment, two groups of FINS, FC - P, 2 hins, 2 hc - P, HOMA - significantly higher than before treatment (P < 0.01), FPG, 2 HPG, HOMA - IR decreased obviously (P < 0.01);Comparison between the two groups, before and after treatment of FINS, FC - P, 2 hc - P, HOMA, FPG, 2 HPG, HOMA IR no statistical difference (P > 0.05), the frequency of hypoglycemia occurred no statistical difference (P > 0.05) to standard time (2.46 + 0.78) d insulin pump group was obviously shorter than insulin analogue group (5.42 + 1.76), d (P < 0.05), the standard daily dosage of insulin analogue insulin pump group (31.25 + 9.12) U/d, slightly less than insulin analogue subcutaneous injection group (36.43 + 8.24 U/d), but no statistical difference (P > 0.05).Were folowed up for 6 months, two groups of patients under your eating and exercise therapy, most blood glucose control is good, should be the proportion of drug treatment has no obvious difference.Conclusion:Insulin analogue short-term intensie treatment new T2DM can obviously improve the function of islet beta cels, reduce insulin resistance, make the most of the blood sugar was higher T2DM patients without medication for a long time, good control of blood sugar, desirable intensively treated with insulin pump similar effect.

InsulinShort-acting insulin analogueShort-term insulin pump intensive treatmentNew type 2 diabetes

甘精胰岛素 速效胰岛素类似物 胰岛素泵短期强化治疗 初诊2型糖尿病

2014

中国保健营养(中旬刊)
全国卫生产业企业管理协会

中国保健营养(中旬刊)

ISSN：1004-7484
年,卷(期)：2014.(6)
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