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非酒精性脂肪肝不同分度与超敏C反应蛋白之间的关系

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目的:探讨并分析非酒精性脂肪肝病(NAFLD)患者不同分度与超敏 C反应蛋白(HS-CRP)的关系。方法:选取109例确诊为NAFLD 患者,通过影像学检查进行脂肪肝声像图分度并接受生化检查,分为轻度、中度及重度脂肪肝。比较三组血清HS-CRP 的水平,所有患者在 HS-CRP 不同水平间各项指标(ALT、AST、TB、GGT、LDL-C、CHOL、HDL-C和TG)进行比较。结果:轻度脂肪肝组的 HS-CRP 平均水平为(3.3±2.6)mg/L,中度脂肪肝组HS-CRP 水平为(5.8±3.7) mg/L,重度脂肪肝组 HS-CRP 水平(7.3±3.5)mg/L。所有患者在 HS-CRP 不同水平间各项指标比较中,以0~3mg/L 区域的为标准组,3.1-6mg/L 区域的各个指标与其比较差异性不大,而6.1~9mg/L、>9mg/L 两个区域的ALT、AST、TB、GGT、LDL-C、CHOL和TG与其相比差异性明显(P<0.05)。结论:NAFLD患者脂肪肝不同分度与 HS-CRP 密切相关, HS-CRP可作为评估 NAFLD 病程发展的重要指标。
Relationship between different levels of NAFL and HS-CRP
Objective:To investigate and analyse the relationship between different degrees of non-alcoholic faty liver and high-sensitivity C-reactive protein (HS-CRP) in patients with non-alcoholic faty liver disease (NAFLD).Methods:109 patients with NAFLD were selected and divided into three groups ,namely mild,moderate and severe degree of faty liver,according to patients’ ultrasound, CT and biochemical tests results. Serum HS-CRP levels from three groups and the indicators (ALT, AST, TB, GGT, LDL-C, CHOL, HDL-C and TG) of different HS-CRP levels from al patients were compared. Results the average level of HS-CRP was(3.3±2.6)mg/L in the mild group,(5.8±3.7)mg/L in the moderate group and(7.3±3.5)mg/L in the severe one. In the comparison of indicators (ALT, AST, TB, GGT, LDL-C, CHOL, HDL-C and TG) of different HS-CRP levels, the indicators of the HS-CRP level in the range of 3.1-6mg/L has no significant difference with the the standard group with the level in the 0~3mg/L range, while the indicators (ALT, AST, TB, GGT, LDL-C, CHOL and TG)of the two groups with the HS-CRP level in the 6.1~9mg/L and over 9mg/L range were significantly different from the standard group(P<0.05). Conclusions:The varing degrees of the faty liver in patients with NAFLD was closely related to the level of HS-CRP ,thus HS-CRP can be used as an important indicator to evaluatethe development of NAFLD.thus HS-CRP can be used as an important indicator of the assessment of the development of NAFLD.

non-alcoholic faty liver diseasehigh-sensitivity C-reactive protein

非酒精性脂肪肝 超敏C反应蛋白

2014

中国保健营养(中旬刊)
全国卫生产业企业管理协会

中国保健营养(中旬刊)

ISSN:1004-7484
年,卷(期):2014.(6)
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