摘要
目的：通过检测血清Bcl-2、血管内皮生长因子的水平，以研究其在肝癌中表达的意义。方法：选取2011年2月～2012年12月入我院经临床确诊为50例肝癌患者为观察组，50例正常者为对照组。检测两组患者血清 Bcl-2、血管内皮生长因子的含量及表达阳性率，并分析比较检测结果。结果：观察组患者血清 Bcl-2、血管内皮生长因子的表达阳性率均明显大于对照组（98%>20%、100%>30%），两组相比较差别具有统计学意义（P<0.05）；观察组和对照组的血清Bcl-2的水平分别为（102±40） U/L、（45±30）U/L，观察组显著高于对照组，两组相比较差别具有统计学意义（P<0.05）；观察组和对照组的血管内皮生长因子水平分别为（415.2±140.3）ng/L、（160.5±65.8）ng/L，观察组明显高于对照组，两组相比较差别具有统计学意义（P<0.05）。结论：肝癌患者的血清Bcl-2、血管内皮生长因子检出率明显高于正常者，且血清中含量多于正常者，对肝癌疾病的预后及治疗有着重要的临床意义。
Abstract
To detect serum Bcl-2, vascular endothelial growth factor levels in order to study the significance of its expression in HCC .Methods:February 2011 - December 2012 into the hospital clinicaly diagnosed 50 cases of liver cancer patients in the observation group, 50 cases of normal control group. Serum were detected Bcl-2, vascular endothelial growth factor levels and positive expression rate, compare and analyze the test results.Results:The serum Bcl-2, vascular endothelial growth factor expression positive rate was significantly higher than the control group ( 98% > 20% and 100 %> 30% ) , compared to the difference between the two groups was statisticaly significant (P <0.05 ) ; serum levels of Bcl-2 in the observation group and the control group were (102 ± 40) U / L, (45 ± 30) U / L, the observation group was significantly higher , compared to the difference between the two groups was statisticaly significance (P <0.05); observation group and the control group of vascular endothelial growth factor levels were (415.2 ± 140.3) ng / L, (160.5 ± 65.8) ng / L, the observation group was significantly higher, compared to the two groups the difference was statisticaly significant (P <0.05).Conclusion:The serum of patients with hepatocelular carcinoma Bcl-2, vascular endothelial growth factor detection rate was significantly higher than normal, and the serum levels than normal , prognosis and treatment of liver disease has important clinical significance.
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