To assess the serum levels of D-lactate, intestinal faty acid binding protein(I-FABP),C-reactive protein(CRP),and to analyze its relationship with systemic inflammatory response in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:Subjects were divided into ventilation group,no-ventilation group and control group according to the standard.Then the serum D-lactate,I-FABP and CRP of al the subjects were detected and analyzed.Results:The serum levels of D-lactate,I-FABP and CRP in ventilation group and no-ventilation group were higher than those in control group(P﹤0.01);and those in ventilation group were higher than those in no-ventilation group(P﹤0.01).There were positive correlations between the serum levels of D-lactate,I-FABP and CRP in observation group.Conclusion:Intestinal mucosa barrier may have been injured in patients with AECOPD,and would get worse as the severity of AECOPD increase; A positive association was present between intestinal mucosal injury and systemic inflammatory response.
chronic obstructive pulmonary diseaseD-lactateintestinal faty acid binding proteinC-reactive protein
NETL
NSTL
万方数据
