慢性阻塞性肺疾病急性加重期患者早期肠黏膜屏障功能障碍的临床研究
李轲 1武焱旻 1卓志远1
作者信息
- 1. 徐州市中心医院呼吸内科 江苏 徐州 221009
- 折叠
摘要
目的：探讨血清D-乳酸、肠脂肪酸结合蛋白(I-FABP)和C-反应蛋白(CRP)水平在慢性阻塞性肺疾病急性加重期(AECOPD)中的变化及临床意义，了解AECOPD患者早期肠黏膜损伤和通透性变化及其与系统性炎症反应关系。方法：将54例AECOPD患者和18例COPD稳定期体检者作为观察组和对照组，观察组分为通气组及非通气组，定量检测血清D-乳酸、I-FABP及CRP水平并分析。结果：血清D-乳酸、I-FABP及CRP水平在观察组显著高于对照组(P﹤0.01)，非通气组低于通气组但高于对照组(P﹤0.01)；相关分析显示观察组血清D-乳酸、I-FABP与CRP均呈正相关。结论：AECOPD早期存在肠黏膜损伤及通透性变化，病情越重肠黏膜损伤越重，其与系统性炎症反应密切相关。
Abstract
To assess the serum levels of D-lactate, intestinal faty acid binding protein(I-FABP),C-reactive protein(CRP),and to analyze its relationship with systemic inflammatory response in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:Subjects were divided into ventilation group,no-ventilation group and control group according to the standard.Then the serum D-lactate,I-FABP and CRP of al the subjects were detected and analyzed.Results:The serum levels of D-lactate,I-FABP and CRP in ventilation group and no-ventilation group were higher than those in control group(P﹤0.01);and those in ventilation group were higher than those in no-ventilation group(P﹤0.01).There were positive correlations between the serum levels of D-lactate,I-FABP and CRP in observation group.Conclusion:Intestinal mucosa barrier may have been injured in patients with AECOPD,and would get worse as the severity of AECOPD increase; A positive association was present between intestinal mucosal injury and systemic inflammatory response.
关键词
慢性阻塞性肺疾病/D-乳酸/肠脂肪酸结合蛋白/C-反应蛋白Key words
chronic obstructive pulmonary disease/D-lactate/intestinal faty acid binding protein/C-reactive protein引用本文复制引用
出版年
2014
NETL
NSTL
万方数据