neonatal hypoxic ischemic encephalopathy (HIE) as a clinical severe, with mortality, associated with cerebral palsy, epilepsy and learning difficulties and sequelae after treatment, is an important cause of neonatal disabled. Nowadays, with the development of science and the perinatal, neonatal hypoxic ischemic encephalopathy (HIE) related research work steadily, provides a new thinking for the development of clinical diagnosis and treatment work. This paper analyzes and summarizes the new progress in the study of the diagnosis and treatment of HIE.