The correlation analysis of asthma fractional exhaled nitric oxide and bronchial provocation tests
Objective To compare the value of fractional exhaled nitric oxide(FeNO) and methacholine bronchial provocation test(BPT) the degree of asthma control status. To investigate the correlation analysis between them and evaluate the clinical value in diagnosis and treatment of asthma.Methods:We selected 42 cases non-acute episode asthma join in the testing from Clinic of Respiratory Medicine in 2012.1-2013.10 Xinxiang city centre Hospital. Diagnostic criteria are in line with "Global Initiative for Asthma" (GINA 2009) and "Asthma Prevention Guideline" revised by the Chinese Medical Association, 2008.There is 18 cases in Normal group. Before the test, the selected candidates are asked to sign an informed consent. First we performed fractional exhaled nitric oxide test, then pulmonary function tests, and finaly Methacholine bronchial provocation test. The Methacholine provocative concentration PC20 when application FEV1 decreased by 20% evaluate airway reactivity. Fractional exhaled nitric oxide test evaluate the airway inflammation. Adverse reactions were observed among the test.Results There were a total of 60 people participated in the test. There were seven cases to exit the test. There were 53 cases completed the fractional exhaled nitric oxide and pulmonary function tests ,so as to methacholine bronchial provocation test, which divided into 15 cases of asthma control group, 13 cases of partial control group, 10 cases of uncontrol group, normal group of 15 cases. The result were significantly different in fractional exhaled nitric oxide and bronchial provocation test lnPC20 between Asthma and the normal group, statisticaly significant, P <0.05. The FVC showed no significant difference between Asthma and the normal group. no statistical significance,P> 0.05. Linear correlation analysis results display: the control group fractional exhaled nitric oxide and bronchial provocation test lnPC20 has linear correlation, negative correlation. (r = -0.971, P <0.05).The partial control group fractional exhaled nitric oxide and bronchial provocation test lnPC20 has linear correlation, negative correlation. (r = -0.948,P <0.05) .The uncontrol group fractional exhaled nitric oxide and bronchial provocation test lnPC20 has linear correlation, negative correlation. (r = -0.969,P <0.05)Conclusion:1. Fractional exhaled nitric oxide can not assessed asthma control status isolate .It requires a comprehensive ways.2. Fractional exhaled nitric oxide and bronchial provocation test PC20 was negative correlation with fractional exhaled nitric oxide.3. In the part of clinical diagnosis and treatment evaluation, the Fractional exhaled nitric oxide is an important method of measuring airway inflammation. Bronchial provocation test can be partialy replaced by Fractional exhaled nitric oxide in the evaluation of asthma airway inflammation and airway hyper responsiveness.
NETL
NSTL
万方数据
