To investigate the analgesic effect ofpropofol injection combined with misoprostol for painless abortionin the elderly. Methods: from January to 2012 the voluntaryrequest in 2010 December in our hospital were aged for painless artificial abortion women in 80 cases, and no operationcontraindication for al patients. Al the pregnant women were randomly divided into the observation group and the control group, the observation group anesthesia using propofol and misoprostol in control group, propofol alone, compared to theanalgesic effect of the two groups. Results: the total efficiency ofthe observation group analgesia is obviously higher than that of control group, intraoperative uterine softening efficiency is significantly larger than that of the control group, operation time and postoperative recovery time was significantly less than that of the control group, and the P< 0.05. Conclusion: application ofpropofol injection combined with misoprostol in elderly painless abortion efficacy, good analgesia, can shorten the operation time,is worth the clinical promotion.