To investigate the clinical effect of Ethiopian Mira combined with itopride in the treatment of senile reflux esophagitis.Methods: 60 cases of elderly patients with reflux esophagitis were randomly divided into two groups. The treatment group was given with 20mg Ethiopian Mira, oral, 2 times a day. Itopride hydrochloride 50mg, oral, 3 times a day. The control group was given ranitidine 150mg, oral, 2 times a day. Treatment for 8 weeks, curative effects were compared between the two groups of clinical symptoms and endoscopic changes.Results: the treatment group and the control group in the clinical and endoscopic changes were significant difference (P<0.01). Conclusion: the Ethiopian Mira aripiprazole and itopride in the treatment of senile esophagitis curative effect is beter than that of cimetidine combined with itopride.