Low doses of paclitaxel plus weeks cobalt 60 radiation treatment of patients with clinical observation
to observe the week low doses of paclitaxel plus cobalt 60 radiation treatment of patients with curative effect and adverse reaction of patients.Methods:patients were randomly divided into two groups, 60 cases of patients with (cobalt 60 radiotherapy plus paclitaxel) put the group 30 cases, single put group 30 cases (pure cobalt 60 radiation). Two groups al use cobalt 60 external irradiation treatment, the total dose of 60 ~ 63 gy, 6 ~ 6.3 weeks to complete; Put the group with low doses of paclitaxel combined radiotherapy cobalt 60 per week, paclitaxel 60 mg /㎡, for six weeks. Results: the group and single set of CR (complete response), PR (partial response), SD (stability), PD (progress) percentage was 56.25% 56.25% 25.81% 19.35% 16.13% 6.25% 6.25% and 3.13%, two groups of comparative differences are statisticaly significant (P < 0.05). Put a group of hematology toxicity, radioactive esophagitis, the incidence of gastrointestinal reaction is put group is a bit high, but the patients tolerated.Conclusion: low dose weekly paclitaxel plus radiation therapy can obviously improve the curative effect of treatment of patients with cobalt 60, adverse reaction is increased, but the patients tolerated, does not affect the normal treatment, and the end of treatment, folow-up 1 month toxic and side reaction were much improved.
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