Objective To study the sputum suction oxygen filling joint enclosed on hypoxemia after mechanical ventilation in patients with sputum aspiration .Meth-ods ICU63 mechanical ventilation patients as the research object,were randomly divided into control group(open sputum suction,29 cases)and the experimental group ( enclosed sputum suction,33 cases) ,sputum suction closed group of patients with sputum suction to pure oxygen absorption before 1 minute,sputum suction,after 5 mi-nutes before the sputum suction extraction arterial blood check PaO2,SaO2,respectively.Results Before and after the sputum suction PaO2 changes:the experimental group patients were 89.4 ±12.2mmHg and 83.1 ±12.4 mmHg,P>0.05,there was no statistically significant difference,the control group patients were 91.2 ±15.4 mmHg and 83.1 ±12.4mmHg,P<0.05;Patients with sputum suction SaO2 before and after the change:The experimental group were 95.3%plus or minus 2.7%,92. 8%plus or minus 2.8%and P>0.05,there was no statistically significant difference,the control group patients were 94.9%plus or minus 2.7%,85.4%plus or minus 3.7%,P<0.05,the difference was statistically significant.Conclusion Beforehand oxygenation combined enclosed sputum suction can effectively prevent hypoxemia af-ter sputum suction.