Objective To study the clinical application of nuclear medicine imaging department of orthopedics .Methods Selected in our hospital 80 patients’ pain and pathologic fracture patients as the research object .Results The nuclear medical molecular imaging findings ,patients including 22 cases of primary hyperparathyroid-ism metabolic bone disease,10 cases of primary benign,malignant tumor and bone pain,25 cases of soft bone and kidney bone disease,7 cases of joint problems and met-abolic bone disease,13 cases of bone softening and renal osteodystrophy,the remaining three patients no serious diseases.Conclusion The application of nuclear medicine in the diagnosis of diseases in Department of orthopedics in molecular imaging techniques can improve the accurate rate of disease diagnosis ,is worthy to be popularized in clinical application .