脑白质病变与老年抑郁症的临床分析
Clinical Analysis of White Matter Lesions and Late Life Depression
郑垒炬 1王金兰1
作者信息
- 1. 郑州大学第二附属医院，河南 郑州 450000
- 折叠
摘要
目的：探讨脑白质病变与老年抑郁症的关系及临床表现。方法随机抽取120例WML患者，分为Ⅰ度、Ⅱ度、Ⅲ度，并选取30例非 WML的作为对照，均进行抑郁自评量表筛查，再进一步行汉密尔顿抑郁量表评分。结果Ⅰ度抑郁发生率为54．7％；Ⅱ度72．1％；Ⅲ度92．0％，WML的严重程度与老年抑郁的发生呈正相关，差异有统计学意义（χ2＝6．51，P＜0．05）。Ⅱ度、Ⅲ度患者的HAMD评分均高于Ⅰ度及对照组，在抑郁情绪、躯体性焦虑、精神性焦虑、睡眠障碍、全身症状、能力减退方面的评分显著有统计学差异（P＜0．01）。结论 WML程度及部位和 LLD有一定相关性，其病变的程度与 HAMD评分及抑郁症的发生率呈正相关；伴程度不同的WML的LLD患者其临床表现不同。
Abstract
Objective To analyze of the relationship and clinical manifestations between WML and LLD .Methods 120 WML patients and 30 healthy subjects were enrolled.All they were screened using a SDS and those who with depression were further evaluated via HAMD .Results Incidence rate were54.7%,72.1%,and92.0%for three groups.Differences among the groups were statistically significant.(P<0.01).Conclusion Severity of depression might be correlated to severity,location,distri-bution of WML.Varying degrees of WML in LLD clinical manifestations are different .
关键词
脑白质病变/老年抑郁症Key words
White matter lesions/Late life depression引用本文复制引用
出版年
2014
NETL
NSTL
万方数据