Objective To analyze of the relationship and clinical manifestations between WML and LLD .Methods 120 WML patients and 30 healthy subjects were enrolled.All they were screened using a SDS and those who with depression were further evaluated via HAMD .Results Incidence rate were54.7%,72.1%,and92.0%for three groups.Differences among the groups were statistically significant.(P<0.01).Conclusion Severity of depression might be correlated to severity,location,distri-bution of WML.Varying degrees of WML in LLD clinical manifestations are different .
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