Objective To investigate the nursing intervention in patients of advanced gastric cancer with intraperitoneal chemotherapy .Methods To analyze 102 ca-ses of advanced gastric cancer with intraperitoneal chemotherapy in our hospital,and randomly divided into two groups,one group of patients with routine nursing meas-ures for the control group,the other group with effective nursing interventions for the observation group ,compared two groups of patients with therapeutic effect and harm-ful reaction.Results The patients in the observation group after the effect of clinical treatment effective nursing interventions after significantly better than the control group,by comparison with significant difference(P<0.05).Conclusion The patients of advanced gastric cancer with intraperitoneal chemotherapy,through effective in-tervention measures can significantly improve the therapeutic effect of patients ,relieve harmful reaction and improve living quality of patients.