Obejcitve To investigate drug-resistance status and changing tendency of Escherichia coli in my hospital to provide the evidence for reasonable use of antibiotics.Me thods Pathogenic bacteria were isolated and identified according to the national clinical laboratory operation rules .Resu lt The resistance to commonly used antibiotics in Escherichia coli was on the rise the resistance rate to ampicillin was great .Conclusion We must investigate drug-resistance status and changing tendency of Escherichia coli.We should strengthen the management of antibiotil use and control the spread and prevalence of the drug -resistant bacteria.
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