Objective To study the analysis of neonatal hypoxic -ischemic encephalopathy application ganglioside hyperbaric oxygen therapy combined clinical effects.Methods 88 patients in our hospital neonatal hypoxic -ischemic encephalopathy patients were randomly divided into treatment group(44 cases)and control group (44 cases),compared two groups of patients with the therapeutic effect.Results The comparison of the two groups of patients and treatment sequelae occur incidence was statistically significant(P<0.05).Conclusion Ganglioside combined hyperbaric oxygen on neonatal hypoxic -ischemic encephalopathy significant clinical effect,should be widely applied.