To summarize 1 cases of toxic epidermal necrolysis associated with systemic lupus erythematosus ,cardiac function insufficiency patients nursing .In pa-tients with stable mood ,strict implementation of protective measures ,close observation of changes in condition ,to strengthen the nursing of skin and mucosa ,proper nutri-tion,prevention of infection is an important measure of successful treatment of the patients ,the nursing protective isolation measures and skin and mucous membrane is the key.