Objective To investigate the clinical treatment options of helicobacter pylori -positive patients with primary bile reflux gastritis .Methods 90 helicobact-er pylori-positive patients with primary bile reflux gastritis were randomized to the test group or the control group in 1:1 ratio,45 patients per group.The patients in the control group received mosapride plus omeprazole,and the patients in the test group,besides the two drugs described above,also received levofloxacin and amoxicillin. Observe and compare the efficacy and eradication rate between two groups.Results The overall clinical effective rate and eradication rate in the test group (85% and 82%,respectively)were statistically significantly higher than that of the control group(63% and 10%,respectively;P<0.05).Conclusion The helicobacter pylori erad-ication therapy is better for the helicobacter pylori -positive patients with primary bile reflux gastritis .