中国保健营养(上旬刊)2014,Issue(4) :2261-2262.DOI:10.3969/j.issn.1004-7484(s).2014.04.579

一种新型盐酸氨溴索组合物注射液的制备

Preparation of a new Injection of Ambroxol Hydrochloride Compound

曹传 郭磊 王兴慧
中国保健营养(上旬刊)2014,Issue(4) :2261-2262.DOI:10.3969/j.issn.1004-7484(s).2014.04.579

一种新型盐酸氨溴索组合物注射液的制备

Preparation of a new Injection of Ambroxol Hydrochloride Compound

曹传 1郭磊 1王兴慧1
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作者信息

  • 1. 山东罗欣药业股份有限公司,山东 临沂 276017
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摘要

以添加柠檬酸和枸橼酸钠为缓冲剂,制备了组分简单的盐酸氨溴索组合物,并进一步制备了盐酸氨溴索组合物注射液。实验结果显示,该注射液在比较高的pH(5.5-7.0)条件下,活性药物盐酸氨溴索的稳定性较高,更适合人体注射,可以明显减少注射时给患者带来的不适感。

Abstract

By adding citric acid and natrium citricum trihydrate as buffer solution ,ambroxol hydrochloride compound with simple component was prepared ,which further to be made into form of injection.Related results indicated that be alive pharmacy material of injection showed higher stability under high pH range from 5.5 to 7.0,which is more suitable for human injection,resulting in fewer uneasy feeling for patient.

关键词

缓冲剂/盐酸氨溴索组合物/稳定性/注射液

Key words

Buffer solution/Ambroxol hydrochloride compound/Stability/Injection

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出版年

2014
中国保健营养(上旬刊)
全国卫生产业企业管理协会

中国保健营养(上旬刊)

ISSN:1004-7484
参考文献量1
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