目的：探讨哮喘患者中幽门螺杆菌（Hebcobacter pylori，Hp）的感染情况及其临床意义。方法将180例哮喘患者分为儿童组和成人组，计算各组HP感染率，分别与对照组比较，并做组间比较。并将哮喘患者根据有无Hp感染分组，测定肺功能并进行比较。用13C呼气试验（13C -UBT）法检测病人幽门螺杆菌感染情况。结果180例哮喘病人中，56名患者Hp感染，阳性率为31．11％；110例对照组中48人 Hp 感染，阳性率为43．64％（p＝0．031）。其中儿童哮喘患者Hp感染率较其正常对照明显降低，而成人哮喘患者 Hp 感染率与正常对照无明显差异。哮喘患者合并 Hp感染后其肺功能明显下降。结论幽门螺杆菌感染与哮喘呈负相关，在儿童组较明显。哮喘合并Hp感染后会加重肺损伤。
Clinical analysis of asthmatics with Helicobacter pylori infection
Objective To investigate the role of Helicobacter pylori(Hp)infection in asthmatics.Methods We divided 180 asthmatics into two groups(children and adults)according to the age.Hp infection was detected using 13C-UBT.The infection rate between each group was mesured by t -test using SPSS 17.0.Result The in-fetion rate of Hp was significantly lower in asthmatics than controls(p=0.031),espeially among children.Asthamatics with Helicobacter pylori infection had worse lung fuction than those without Hp infection.Conclusion Helicobacter pylori infection was negatively related to asthma,especially in children group.
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