Recent Advance on New Indocyanine Green IR-820 in Near-Infrared Fluorescence Imaging and Photothermal and Synergetic Therapy of Tumor
With the advantages of strong near-infrared(NIR,760～1700 nm)fluorescence emission,good biocompatibility,high photothermal conversion efficiency and good stability,the new indocyanine green IR-820 has stood out among the existing organic NIR fluorescent dyes and has been widely used in the research fields of biomedic-al imaging,fluorescent labeling,real-time cell monitoring and photothermal therapy.Researchers have modified IR-820 with different biochemical molecules to enhance its fluorescence and photothermal properties,multiple types of IR-820 fluorescent nanoparticles have been prepared and investigated in biomedical imaging and tumor photothermal therapy.This article has summarized the applications of the synthesized IR-820 nanoparticles in near-infrared fluorescence(NIRF)ima-ging and tumor photothermal therapy and synergistic therapy,aiming to provide a reference for the further development of NIR organic fluorescent dye IR-820 in the biomedical field and the further clinical translation.
organic fluorescent dyenew indocyanine green IR-820near-infrared fluorescence(NIRF)imagingphoto-thermal therapysynergistic therapytumor
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