摘要
随着纳米技术的飞速发展,铜纳米粒子因其独特的物理化学性质,如高活性、大比表面积和良好的选择性,在有机合成中展现了广泛的应用前景.讨论了新型铜纳米材料在各种类型有机反应中的应用,包括多组分"一锅法"反应合成药物活性分子、炔-叠氮化合物环加成反应合成三唑和四唑衍生物、醇的选择性氧化反应、硝基的还原反应、C—X(C,N,O)偶联反应(其中 C—C 偶联包括 Mizoroki-Heck、Suzuki-Miyaura、Glaser-Hay 等偶联反应;C—N 及 C—O 偶联包括 Chan-Lam、Buch-wald-Hartwig、Ullmann、Goldberg等偶联反应).大多数铜纳米粒子催化反应具有反应操作简单、反应条件温和、催化效率高、官能团耐受性好、成本低、反应体系干净且铜催化剂可重复使用等优点.铜纳米粒子在有机合成中的应用将对有机合成方法学产生重要影响,并促进有机铜化学的进一步发展.
Abstract
With the rapid development of nanotechnology,copper nanoparticles have shown a broad application prospect in organic synthesis due to their unique physical and chemical properties,such as high activity,large specific surface area and good selectivity.This review discusses the application of new copper nanomaterials in various types of organic reactions,including multi-component"one pot"reaction for the synthesis of drug active molecules,acetylene azide cycloaddition reac-tion for the synthesis of triazole and tetrazole derivatives,selective oxidation of alcohols,reduction of nitro groups,C—X(C,N,O)coupling reactions(C—C coupling includes Mizoroki-Heck,Suzuki-Miyaura,Glaser-Hay and other coupling reactions;C—N and C—O coupling reactions include Chan-Lam,Buchwald-Hartwig,Ullmann,Goldberg,etc.).Most copper nanoparticles catalytic reactions have the advantages of simple operation,mild reaction conditions,high catalytic effi-ciency,good tolerance of functional groups,low cost,clean reaction system and reusable copper catalyst.These applications of copper nanoparticles in organic synthesis will have an important impact on methodology of organic synthesis and promote the further development of organic copper chemistry.
基金项目
西安市科学技术局高校院所人才服务企业项目(2022JH-RYFW-0123)
西安市科学技术局高校院所人才服务企业项目(2023JH-GXRC-0196)
陕西省重点研发计划项目(2022ZDLSF07-04)
维普
万方数据