Research Progress in the Modification of Antibacterial Coatings on Titanium Base Implants
Titanium and its alloy are the main matrix materials for the repair and replacement of bone,teeth and other hard tissues that need to bear a high load due to their advantages of non-toxic,light weight,corrosion resistance,machinability and good biocompatibility,and are widely used in clinical practice.However,untreated titanium surface usually does not have antibacterial properties,which is easy to cause implant infection,resulting in implantation failure.Therefore,it is nec-essary to construct antibacterial coating on the surface of titanium implant to give it antibacterial ability.Studies have shown that inhibiting early bacterial adhesion and biofilm formation are the main strategies to prevent and control infection.Starting from the aspect of antibacterial mechanism,this paper reviews the latest research progress of anti-adhesion antibacterial coat-ing,release bactericidal coating and contact bactericidal coating,focuses on the photodynamic bactericidal and pH response bactericidal two new bactericidal methods,and summarizes the cooperative bactericidal strategy of multiple antibacterial a-gents.Finally,the future development of antibacterial coating on the surface of titanium implants is prospected.
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维普
