Study on monitoring of coagulation markers after intravenous thrombolysis in acute cerebral infarction
Objective To monitor the changes of coagulation markers after intravenous thrombolysis in acute cerebral infarction and explore the most suitable time window for the application of anticoagulants.Methods A total of 86 patients with acute cerebral infarction treated with intravenous thrombolysis at Liaocheng Chiping District People's Hospital from May 2019 to April 2021 were selected as the observation subjects.The changes in coagulation biomarker values of patients at different time points after admission and thrombolysis treatment were dynamically observed.The patients were randomly divided into observation group and control group,with 43 cases in each group,using computer random grouping method.The control group was given low molecular weight heparin calcium 24 hours after thrombolysis,while the observation group was given low molecular weight heparin calcium 6 hours after thrombolysis.The recovery of neurological function and daily living ability between two groups were compared.Results After medication,the FIB content significantly decreased,the FIB content at t1-t6 were lower than that at t0,and the differences were statistically significant(P＜0.05).The TT,PT and APTT values at t1-t6 were longer than those at t0,and the differences were statistically significant(P＜0.05);after thrombolysis,the values of D-D,TAT and F1+2 indicators at each time period were sinificantly higher than those at t0,and the differences were statistically significant(P＜0.05).After 21 days of treatment,the ESS score and MBI of the observation group were higher than those of the control group,and the differences were statistically significant(P＜0.05).Conclusion After intravenous thrombolysis treatment in acute cerebral infarction,there was a significant change in coagulation biomarker values.Fib values increased significantly after 6 hours of thrombolysis,and APTT,PT and TT shortened significantly.Anticoagulants should be added in a timely manner to reduce the risk of re-occlusion after thrombolysis.
万方数据
维普
